VMN dopaminergic graft and feeding pattern in obese Zucker rats
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چکیده
منابع مشابه
Dopaminergic modulation of ventilation in obese Zucker rats.
To investigate the hypothesis that the impaired respiratory drive noted in morbid obesity was attributable to altered dopaminergic mechanisms acting on peripheral and/or central chemoreflex sensitivity, seven obese and seven lean Zucker rats were studied at 11 wk of age. Ventilation (VE) was measured by the barometric technique during hyperoxic (100% O(2)), normoxic (21% O(2)), hypoxic (10% O(2...
متن کاملExpression of dopaminergic receptors in the hypothalamus of lean and obese Zucker rats and food intake.
As revealed by previous microdialysis studies, basal and food intake-accompanied dopamine release significantly differs in the hypothalamus of obese vs. lean Zucker rats. In the present study, we determined whether dopaminergic receptors are also compromised in obesity. Dopaminergic D(1) and D(2) receptor mRNA expression was studied in the ventromedial hypothalamus (VMH), lateral hypothalamic a...
متن کاملCorticosterone-dependent metabolic and neuroendocrine abnormalities in obese Zucker rats in relation to feeding.
The obese Zucker (fa/fa) rat is characterized by hyperphagia, hyperinsulinemia, an increase in fat deposition, and a hyperactivity in the hypothalamic-pituitary-adrenal (HPA) axis. The HPA axis in fa/fa rats is hypersensitive to stressful experimental conditions. Food deprivation even leads to a stress reaction in obese fa/fa rats. The present study was conducted to investigate the role of cort...
متن کاملAttenuated PGI2 synthesis in obese Zucker rats.
In obesity, skeletal muscle blood flow during exercise (functional hyperemia) is impaired. We have indirectly demonstrated that an altered arachidonic acid metabolism is responsible for the impaired functional vasodilation in the obese Zucker rat (OZR), a model of obesity. In this study, we tested the hypothesis that there is an impaired release of PGI(2) due to a nitration of PGI(2) synthase (...
متن کاملsuckling and weaning obese Zucker rats
The aim of this study was to determine whether the increase in lipoprotein lipase activity displayed by the adipose tissue of obese (Ja/fa) rats as compared with that of lean (Fa/fa) rats could be ascribed to a change in the content or in the catalytic properties of the enzyme. The question was addressed in rats of two ages: in 7-day-old suckling and in 30-day-old post-weaning pups. Inguinal fa...
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ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 2000
ISSN: 0307-0565,1476-5497
DOI: 10.1038/sj.ijo.0801161